Christine A. Ziegler

Postdoctoral Associate
Contact Information
MIT 48-424
15 Vassar Street
Cambridge, MA 02139
Email: czieg at
2022     Ph.D. Biological Chemistry, University of Michigan, Ann Arbor, MI
2016     B.S. Chemistry with Highest Distinction, University of Rochester, Rochester, NY
2016     B.S. Molecular Genetics, University of Rochester, Rocehster, NY
  1. Ziegler, C.A. and Freddolino, P.L. (2022) E. coli Leucine-responsive regulatory protein bridges DNA in vivo and tunably dissociates in the presence of exogenous leucine. BioRxiv DOI: 10.1101/2022.03.07.483379
  2. Ziegler, C.A. and Freddolino, P.L. (2021) The Leucine-responsive Regulatory Proteins/Feast-Famine Regulatory Proteins: an ancient and complex class of global transcriptional regulators that control metabolism, nutrient transport, virulence, motility, stress tolerance, and antibiotic resistance in bacteria and archaea. Crit Rev Biochem Mol Bio. 56(4):373-400
  3. Zamora, M.*; Ziegler, C.A.*; Freddolino, P.L.; Wolfe, A.J. (2020) A thermosensitive, phase-variable epigenetic switch: pap revisited. Micro and Mol Bio Revs. 84(3):e00030-17.    * Authors contributed equally
  4. Owens, A.C.; Grasso, K.T.; Ziegler, C.A.; Fasan, R. (2017) Two-tier screening platform for directed evolution of amino-acyl tRNA synthetases with enhanced stop codon suppression efficiency. Chem Bio Chem. 18(12):1109-1116.
  5. Causton, H.C.; Feeney, K.A.; Ziegler, C.A.; O’Niell, J.S. (2015) Metabolic cycles in yeast share features conserved among circadian rhythms. Curr. Biol. 25(8):1056-1062.