Libusha Kelly

Postdoctoral Associate
Civil and Environmental Engineering
MIT 48-209
15 Vassar Street
Cambridge, MA 02139
Phone: Phone: (617) 253-2796
Fax: (617) 258-7009
Email: libusha at mit.edu

Education:

1997 B.A. Human Biology, Stanford University
2008 Ph.D. Biological and Medical Informatics, UCSF

Research Interests:

I am interested in examining the role of genetic diversity in ecosystem dynamics.

Publications:

Sullivan MB, Krastins B, Hughes JL, Kelly L, Chase M, Sarracino D, Chisholm SW (2009)
The genome and structural proteome of an ocean siphovirus: a new window into the cyanobacterial 'mobilome'.
Environ Microbiol 11: 2935-2951.

Pieper U, Eswar N, Webb BM, Eramian D, Kelly L, Barkan DT, Carter H, Mankoo P, Karchin R, Marti-Renom MA, Davis FP, Sali A (2009)
MODBASE, a database of annotated comparative protein structure models and associated resources.
Nucleic Acids Res 37: D347-354.

Pieper U, Chiang R, Seffernick JJ, Brown SD, Glasner ME, Kelly L, Eswar N, Sauder JM, Bonanno JB, Swaminathan S, Burley SK, Zheng X, Chance MR, Almo SC, Gerlt JA, Raushel FM, Jacobson MP, Babbitt PC, Sali A (2009)
Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies.
J Struct Funct Genomics 10: 107-125.

Li M, Hays FA, Roe-Zurz Z, Vuong L, Kelly L, Ho CM, Robbins RM, Pieper U, O'Connell JD, 3rd, Miercke LJ, Giacomini KM, Sali A, Stroud RM (2009)
Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening.
J Mol Biol 385: 820-830.

Kelly L, Pieper U, Eswar N, Hays FA, Li M, Roe-Zurz Z, Kroetz DL, Giacomini KM, Stroud RM, Sali A (2009)
A survey of integral alpha-helical membrane proteins.
J Struct Funct Genomics.

Hays FA, Roe-Zurz Z, Li M, Kelly L, Gruswitz F, Sali A, Stroud RM (2009)
Ratiocinative screen of eukaryotic integral membrane protein expression and solubilization for structure determination.
J Struct Funct Genomics 10: 9-16.

Kelly L, Karchin R, Sali A.
Protein Interactions and Disease Phenotypes in the ABC Transporter Superfamily.
Pac Symp Biocomput. 2007 :51-63.

Soranzo N, Kelly L, Martinian L, Burley MW, Thom M, Sali A, Kroetz DL, Goldstein DB, Sisodiya SM.
Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.
Epilepsia. 2007 Apr;48(4):674-83.

Nguyen TD, Gow JM, Chinn LW, Kelly L, Jeong H, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson E, Taylor T, Ferrin TE, Sali A, Giacomini KM, Kroetz DL.
PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network.
Pharmacol Rev. 2006 Mar;58(1):1-2.

Pieper U, Eswar N, Davis FP, Braberg H, Madhusudhan MS, Rossi A, Marti-Renom M, Karchin R, Webb BM, Eramian D, Shen MY, Kelly L, Melo F, Sali A.
MODBASE: a database of annotated comparative protein structure models and associated resources.
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D291-5.

Karchin R, Diekhans M, Kelly L, Thomas DJ, Pieper U, Eswar N, Haussler D, Sali A.
LS-SNP: large-scale annotation of coding non-synonymous SNPs based on multiple information sources.
Bioinformatics. 2005 Jun 15;21(12):2814-20. Epub 2005 Apr 12.

Karchin R, Kelly L, Sali A.
Improving functional annotation of non-synonymous SNPs with information theory.
Pac Symp Biocomput. 2005:397-408.

Olivier M, Bustos VI, Levy MR, Smick GA, Moreno I, Bushard JM, Almendras AA, Sheppard K, Zierten DL, Aggarwal A, Carlson CS, Foster BD, Vo N, Kelly L, Liu X, Cox DR.
Complex High-Resolution Linkage Disequilibrium and Haplotype Patterns of Single-Nucleotide Polymorphisms in 2.5 Mb of Sequence on Human Chromosome 21.
Genomics November 2001; 78: 64-72

Olivier M, Aggarwal A, Allen J, Almendras AA, Bajorek ES, Beasley EM, Brady SD, Bushard JM, Bustos VI, Chu A, Chung TR, De Witte A, Denys ME, Dominguez R, Fang NY, Foster BD, Freudenberg RW, Hadley D, Hamilton LR, Jeffrey TJ, Kelly L, Lazzeroni L, Levy MR, Lewis SC, Liu X, Lopez FJ, Louie B, Marquis JP, Martinez RA, Matsuura MK, Misherghi NS, Norton JA, Olshen A, Perkins SM, Perou AJ, Piercy C, Piercy M, Qin F, Reif T, Sheppard K, Shokoohi V, Smick GA, Sun WL, Stewart EA, Fernando J, Tejeda, Tran NM, Trejo T, Vo NT, Yan SC, Zierten DL, Zhao S, Sachidanandam R, Trask BJ, Myers RM, Cox DR.
A High-Resolution Radiation Hybrid Map of the Human Genome Draft Sequence.
Science 2001 February 16; 291: 1298-1302